Pour aller plus loin
Livres, articles fondateurs, logiciels et communautés pour approfondir. Les liens d'articles pointent vers PubMed ; les outils vers leur site officiel.
Modèles de covariables
- article Covariate model
- article [INDIVIDUAL]: Defining parameter distributions
- article Learning pharmacometric covariate model structures with symbolic regression networks DOI 10.1007/s10928-023-09887-3
- article Automated covariate model building within NONMEM DOI 10.1023/A:1011970125687
- article Covariate modeling in pharmacometrics: General points for consideration DOI 10.1002/psp4.13115
- article Discovering Symbolic Models from Deep Learning with Inductive Biases
Omiques et pharmacométrie
- article STROBE-ME: an extension of the STROBE statement that is specific to molecular epidemiology DOI 10.1371/journal.pmed.1001117
- article A survey of best practices for RNA-seq data analysis DOI 10.1186/s13059-016-0881-8
- article Selection bias in gene extraction on the basis of microarray gene-expression data DOI 10.1073/pnas.102102699
- article Mediation analysis: a practitioner's guide DOI 10.1146/annurev-publhealth-032315-021402
- article Marginal structural models and causal inference in epidemiology DOI 10.1097/00001648-200009000-00011
- article On the dependency of cellular protein levels on mRNA abundance DOI 10.1016/j.cell.2016.03.014
- article Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology DOI 10.1038/clpt.2012.65
Livres de référence
- livre Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications ISBN 9789198299106
- livre Pharmacokinetic-Pharmacodynamic Modeling and Simulation ISBN 9781441994844
- livre Pharmacometrics: The Science of Quantitative Pharmacology ISBN 9780471677833
- livre Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models ISBN 9780470582299
- livre Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications ISBN 9780781750097
- livre Pharmacokinetics ISBN 9780824710422
- livre Nonlinear Models for Repeated Measurement Data ISBN 9780412983412
- livre Mixed Effects Models for the Population Approach ISBN 9781482226508
- livre An Introduction to Copulas (théorème de Sklar, copules archimédiennes, dépendances de queue) DOI 10.1007/0-387-28678-0
- livre The Elements of Statistical Learning (arbres, SVM, boosting, k-means, ACP) ISBN 9780387848570
Tutoriels & mises au point
- article Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development (Parties 1–3) DOI 10.1038/psp.2012.4
- article Basic concepts in physiologically based pharmacokinetic (PBPK) modeling DOI 10.1038/psp.2013.41
- article Modeling and simulation workbench for NONMEM: PsN, Xpose, Pirana DOI 10.1038/psp.2013.24
Fondamentaux PK (articles)
- article Evaluation of methods for estimating population pharmacokinetic parameters (série I–III) DOI 10.1007/BF01060053
- article Forecasting individual pharmacokinetics (la prévision bayésienne individuelle, fondatrice du TDM modélisé) DOI 10.1002/cpt1979263294
- article Mechanism-based concepts of size and maturity in pharmacokinetics (allométrie & maturation) DOI 10.1146/annurev.pharmtox.48.113006.094708
- article Ways to fit a PK model with some data below the quantification limit (méthodes M1–M7) DOI 10.1023/A:1012299115260
- article Clearance: the concept and its use (mise au point) DOI 10.12793/tcp.2015.23.2.42
- article Implementation of a transit compartment model for describing drug absorption (chaîne de transit, k_tr, MTT = n/k_tr) DOI 10.1007/s10928-007-9066-0
- article Statistical moments in pharmacokinetics (AUMC, MRT, Vss = CL·MRT) DOI 10.1007/BF01062109
- article Drug metabolite kinetics (formation-limitée vs élimination-limitée, pente terminale) DOI 10.1016/0163-7258(81)90056-5
PK/PD & modèles pharmacodynamiques
- article Understanding the dose-effect relationship (la référence du modèle Emax et log-linéaire) DOI 10.2165/00003088-198106060-00002
- article The Hill equation: a review of its capabilities in pharmacological modelling (le coefficient de sigmoïdicité) DOI 10.1111/j.1472-8206.2008.00633.x
- article Simultaneous modeling of pharmacokinetics and pharmacodynamics: the effect-compartment model DOI 10.1002/cpt1979253358
- article Comparison of four basic models of indirect pharmacodynamic responses DOI 10.1007/BF01061691
- article General pharmacokinetic model for indirect responses DOI 10.1038/clpt.1994.155
- article Characteristics of indirect pharmacodynamic models (tolérance, rebond, modèle à modérateur) DOI 10.1046/j.1365-2125.1998.00676.x
Survie & modèles joints
- article Nonparametric Estimation from Incomplete Observations (l'estimateur de Kaplan-Meier, la censure à droite) DOI 10.1080/01621459.1958.10501452
- article Regression Models and Life-Tables (le modèle à hasards proportionnels) DOI 10.1111/j.2517-6161.1972.tb00899.x
- article A Time to Event Tutorial for Pharmacometricians (fonction de hasard, S(t), formes paramétriques) DOI 10.1038/psp.2013.18
- article A Joint Model for Survival and Longitudinal Data Measured with Error (le formalisme des modèles joints) DOI 10.2307/2533118
- article DeepSurv: a Cox proportional hazards deep neural network (la survie par apprentissage profond) DOI 10.1186/s12874-018-0482-1
Estimation, validation & design
- article Nonlinear Mixed Effects Models for Repeated Measures Data (la linéarisation dont dérive FO/FOCE) DOI 10.2307/2532087
- article Derivation of various NONMEM estimation methods (FO, FOCE, FOCE-I, Laplace : les formules) DOI 10.1007/s10928-007-9060-6
- article Maximum likelihood estimation in nonlinear mixed effects models (l'algorithme SAEM) DOI 10.1016/j.csda.2004.07.002
- article A new look at the statistical model identification (le critère AIC = −2 log L + 2p) DOI 10.1109/TAC.1974.1100705
- article The large-sample distribution of the likelihood ratio (ΔOFV ~ χ², le seuil 3,84 à 1 ddl) DOI 10.1214/aoms/1177732360
- article Estimating the dimension of a model (le critère BIC = OFV + k·ln n) DOI 10.1214/aos/1176344136
- texte officiel The ASA Statement on p-Values: Context, Process, and Purpose (ce qu'une p-value dit et ne dit pas) DOI 10.1080/00031305.2016.1154108
- article Bootstrap Methods: Another Look at the Jackknife (le rééchantillonnage avec remise) DOI 10.1214/aos/1176344552
- article Optimal design in random-effects regression models (matrice d'information de Fisher en NLME) DOI 10.1093/biomet/84.2.429
- article Automated Covariate Model Building Within NONMEM (la SCM : forward inclusion / backward elimination) DOI 10.1023/A:1011970125687
- article Power, selection bias and predictive performance of the population pharmacokinetic covariate model DOI 10.1023/B:JOPA.0000034404.86036.72
- article Prediction-corrected visual predictive checks (pcVPC) DOI 10.1208/s12248-011-9255-z
- article A tutorial on visual predictive checks
- article Importance of shrinkage in empirical Bayes estimates for diagnostics DOI 10.1208/s12248-009-9133-0
- article Metrics for external model evaluation with an application to NPDE DOI 10.1007/s11095-006-9067-5
- article Conditional weighted residuals (CWRES): a diagnostic for population models DOI 10.1007/s11095-007-9361-x
- article The importance of modeling interoccasion variability in population analyses DOI 10.1007/BF01113502
- article Nonlinear Mixed-Effects Model Development and Simulation Using nlmixr and Related R Open-Source Packages DOI 10.1002/psp4.12445
- article NONMEM Tutorial Part I: description of commands and options, with simple examples of population analysis DOI 10.1002/psp4.12404
- article NONMEM Tutorial Part II: estimation methods and advanced examples DOI 10.1002/psp4.12422
- article Estimation of population pharmacokinetic parameters of saquinavir in HIV patients with the MONOLIX software DOI 10.1007/s10928-006-9043-z
- article Convergence of a stochastic approximation version of the EM algorithm (le fondement mathématique du SAEM) DOI 10.1214/aos/1018031103
- article Parametric and Nonparametric Methods in Population Pharmacokinetics: Experts’ Discussion on Use, Strengths, and Limitations DOI 10.1002/jcph.1993
- article Accurate detection of outliers and subpopulations with Pmetrics, a nonparametric and parametric pharmacometric modeling and simulation package for R DOI 10.1097/FTD.0b013e31825c4ba6
- article An Algorithm for Nonparametric Estimation of a Multivariate Mixing Distribution with Applications to Population Pharmacokinetics DOI 10.3390/pharmaceutics13010042
- article A Tutorial on RxODE: simulating differential equation pharmacometric models in R DOI 10.1002/psp4.12052
TDM & dosage de précision (MIPD)
- article Model-informed precision dosing: state of the art and future perspectives DOI 10.1016/j.addr.2024.115421
- article Better Dosing Through Better Error: Residual Error as a Hidden Lever in Model-Informed Precision Dosing DOI 10.1097/FTD.0000000000001413
- article A hybrid machine learning/pharmacokinetic approach outperforms MAP Bayesian estimation by selectively flattening model priors DOI 10.1002/psp4.12684
- article mapbayr — estimation bayésienne MAP en R DOI 10.1002/psp4.12689
- article Population pharmacokinetic model and Bayesian estimator for two tacrolimus formulations DOI 10.1111/j.1365-2125.2010.03837.x
PBPK
- article Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model (tutoriel) DOI 10.1002/psp4.12134
- article Physiologically-based pharmacokinetics in drug development and regulatory science DOI 10.1146/annurev-pharmtox-010510-100540
- article PBPK modeling in drug discovery and development: a pharmaceutical industry perspective DOI 10.1002/cpt.37
- article Prediction of pharmacokinetics prior to in vivo studies (prédiction mécaniste des Kp par composition tissulaire) DOI 10.1002/jps.10005
- article Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions DOI 10.1002/jps.20502
- article A theoretical basis for a biopharmaceutic drug classification (le BCS : solubilité × perméabilité) DOI 10.1023/A:1016212804288
- article A compartmental absorption and transit model for estimating oral drug absorption (le modèle CAT/ACAT) DOI 10.1016/S0378-5173(99)00147-7
- article Simulation and prediction of in vivo drug metabolism in human populations from in vitro data (l'IVIVE) DOI 10.1038/nrd2173
Oncologie
- article Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth (modèle de Simeoni) DOI 10.1158/0008-5472.CAN-03-2524
- article Model-based prediction of survival from tumor size (TGI-OS, modèle de Claret) DOI 10.1200/JCO.2008.21.0807
- article Tumor growth rates derived from data for patients in a clinical trial (décomposition régression / recroissance) DOI 10.1634/theoncologist.2008-0075
- article Elucidation of relationship between tumor size and survival in non-small-cell lung cancer patients DOI 10.1038/clpt.2009.64
- article Semi-mechanistic model of chemotherapy-induced myelosuppression (Friberg) DOI 10.1200/JCO.2002.02.140
Infectiologie
- article Pharmacokinetic/pharmacodynamic parameters: the founding framework of PK/PD indices DOI 10.1086/516284
- texte officiel Vancomycin therapeutic monitoring: AUC-guided consensus guideline (AUC₂₄/MIC 400–600 in the target setting) DOI 10.1093/ajhp/zxaa036
- article DALI: Defining Antibiotic Levels in Intensive Care Unit patients (sous-exposition des β-lactamines, clairance rénale augmentée) DOI 10.1093/cid/ciu027
- article Viral dynamics of hepatitis C under interferon therapy (décroissance biphasique) DOI 10.1126/science.282.5386.103
- article HIV-1 dynamics in vivo (clairance des virions, durée de vie des cellules infectées) DOI 10.1126/science.271.5255.1582
Anticorps monoclonaux
- article Pharmacokinetics of monoclonal antibodies (FcRn, absorption lymphatique, immunogénicité) DOI 10.1002/psp4.12224
- article Population pharmacokinetics of therapeutic monoclonal antibodies (impact PK des anticorps anti-médicament) DOI 10.2165/11535960-000000000-00000
- article General pharmacokinetic model for target-mediated drug disposition (TMDD) DOI 10.1023/A:1014414520282
- article Approximations of the target-mediated drug disposition model (QSS, rapid-binding) et identifiabilité DOI 10.1007/s10928-008-9102-8
IA & machine learning
- article Support-Vector Networks (naissance des SVM) DOI 10.1007/BF00994018
- article Random Forests DOI 10.1023/A:1010933404324
- article Greedy function approximation: a gradient boosting machine (l'article fondateur du gradient boosting) DOI 10.1214/aos/1013203451
- article XGBoost: A Scalable Tree Boosting System (objectif régularisé au 2e ordre) DOI 10.1145/2939672.2939785
- article CatBoost: unbiased boosting with categorical features (boosting ordonné) DOI 10.48550/arXiv.1706.09516
- article An Introduction to Variable and Feature Selection
- article Variable selection using random forests (VSURF) DOI 10.1016/j.patrec.2010.03.014
- article Ordinal Forests (forêts aléatoires pour une réponse ordinale : grades de toxicité, RECIST) DOI 10.1007/s00357-018-9302-x
- article Distribution of eigenvalues for some sets of random matrices (loi de Marchenko-Pastur) DOI 10.1070/SM1967v001n04ABEH001994
- article On lines and planes of closest fit to systems of points in space (naissance de l'ACP) DOI 10.1080/14786440109462720
- article Analysis of a complex of statistical variables into principal components (l'ACP moderne) DOI 10.1037/h0071325
- article Attention Is All You Need (Transformer, attention softmax(QKᵀ/√d)V) DOI 10.48550/arXiv.1706.03762
- article Language Models are Few-Shot Learners (le passage à l'échelle, l'apprentissage en contexte) DOI 10.48550/arXiv.2005.14165
- article Neural Ordinary Differential Equations DOI 10.48550/arXiv.1806.07366
- article Machine learning to predict tacrolimus AUC for therapeutic monitoring DOI 10.1002/cpt.2123
- article Estimation of drug exposure by machine learning based on simulations from published pharmacokinetic models: the example of tacrolimus DOI 10.1016/j.phrs.2021.105578
Design & essais cliniques
Textes réglementaires & recommandations
- texte officiel Guideline on the Investigation of Bioequivalence (les critères 80–125 %, IC 90 % sur AUC et Cmax)
- texte officiel Bioequivalence Studies With Pharmacokinetic Endpoints for Drugs Submitted Under an ANDA
- texte officiel Statistical Approaches to Establishing Bioequivalence
- texte officiel Guidance for Industry: Population Pharmacokinetics
- texte officiel Guideline on reporting the results of population pharmacokinetic analyses
- texte officiel Guideline on the reporting of PBPK modelling and simulation
- texte officiel Physiologically Based Pharmacokinetic Analyses — Format and Content
- texte officiel Immunogenicity Testing of Therapeutic Protein Products (dosage des ADA, interférence du médicament circulant)
- texte officiel Estimating the Maximum Safe Starting Dose (NOAEL / HED)
- texte officiel Strategies to identify and mitigate risks for first-in-human trials (MABEL)
- texte officiel ICH M15 — General Principles for Model-Informed Drug Development
- texte officiel ICH E4 — Dose-Response Information to Support Drug Registration
- texte officiel Clinical Breakpoint Tables (détermination des CMI, dilutions de raison 2)
Logiciels, laboratoires & communautés
- ressource MLU-Explain — explications visuelles du machine learning
- logiciel PFIM — design optimal en modèles non linéaires à effets mixtes
- logiciel NONMEM — le logiciel historique de la PK de population
- logiciel Monolix / MonolixSuite (SAEM)
- logiciel nlmixr2 — modélisation NLME open-source en R
- logiciel Pmetrics — modélisation de population paramétrique et non paramétrique en R
- logiciel mrgsolve — simulation d'ODE/PK-PD en R
- logiciel Certara — Phoenix NLME & Simcyp (PBPK)
- ressource IATDMCT — International Association of Therapeutic Drug Monitoring and Clinical Toxicology
- ressource IAME — modélisation des maladies infectieuses (Bichat)
- ressource COMPO — Cancer, modélisation & pharmacologie (Marseille)
- ressource van der Schaar Lab — machine learning pour la médecine
- ressource ISoP — International Society of Pharmacometrics
- ressource PAGE — Population Approach Group in Europe